Figure 7

Real time PCR quantification of selected rat mRNAs. Real time PCR and quantitation of message abundance was performed as described in Methods. Relative to the levels in livers from SD rats, expression of mRNAs for both sterolins was increased ~3–5 fold in the SHR livers, as was the message for Srebp-2 (~2 fold). No significant change in SR-B1 or Cyp7a1 for SHR compared to SD liver RNAs was noted. However, the expression of LDL-R was reduced in both WKY and SHR rats.