Skip to main content
Figure 1 | BMC Cardiovascular Disorders

Figure 1

From: HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection

Figure 1

Mevastatin-treated differentiating monocytes are particularly susceptible to apoptosis. After 24 h of statin treatment monocytes still constituted a single, viable cell population (panel A, black arrow). By 48 h this viable monocytic population had decreased in size and a second population of smaller, annexin V-positive cells had appeared (B). By 72 h the majority of monocytes were undergoing apoptosis (C). Conversely, peripheral blood lymphocytes (white arrow) remained largely viable throughout the observation period. Results shown here are representative of 18 experiments (three per individual).

Back to article page

BMC Cardiovascular Disorders

ISSN: 1471-2261

Contact us