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Table 1 Clinical characterization of responders and non-responders to CRT

From: Reduced numbers of regulatory T cells in chronic heart failure seems not to be restored by cardiac resynchronization therapy

 

Global Population Mean ± standard deviation (n = 39)

Responders Mean ± standard deviation (n = 21)

Non-Responders Mean ± standard deviation (n = 18)

P value Responders vs Non-responders

Baseline assessment

 Gender (Male/Female)

26 / 13

14 / 7

12 / 6

1

 Aetiology (Non-Ischemic/Ischemic)

29 / 10

17 / 4

12 / 6

0.418

 NYHA (II/III/IV)

8/ 27/ 4

4/ 16/ 1

4/ 11 /3

0.465

 LV lead position (L/PL/A/AL)

17/11/3/8

12/4/2/3

5/7/1/5

0.228

 Age (years)

61.4 ± 10.5

65.2 ± 9.6

56.9 ± 9.8

0.015

 LVEF (%)

24.9 ± 6.9

23.8 ± 6.5

26.3 ± 7.4

0.309

 LVESV (mL)

190.2 ± 84.9

180.1 ± 55.3

202.1 ± 111.0

0.903

 LVEDV (mL)

244.2 ± 83.9

233.3 ± 58.9

257.1 ± 106.8

0.583

 QRS

148.4 ± 30.6

144.5 ± 22.1

151.4 ± 36.6

0.866

 Total Leukocytes (× 103 µl)

8.4 ± 1.7

8.1 ± 1.6

8.7 ± 1.8

0.242

 hsCRP (mg/L)

5.6 ± 6.0

5.2 ± 5.1

5.9 ± 6.9

0.934

 BNP (pg/mL)

362.8 ± 358.7

264.3 ± 214.8

461.3 ± 448.1

0.362

 Uric Acid (mg/dL)

6.0 ± 1.7

5.6 ± 1.5

6.5 ± 1.9

0.231

 Cholesterol (mg/dL)

185.9 ± 56.5

194.47 ± 61.85

175,81 ± 49.55

0.466

 HDL Cholesterol (mg/dL)

44.4 ± 11.7

48.53 ± 11.04

39,56 ± 10.84

0.031

 LDL Cholesterol (mg/dL)

117.4 ± 46.3

121.47 ± 49.98

111,41 ± 42.33

0.499

 Triglycerides (mg/dL)

132.8 ± 55.2

122.37 ± 50.20

146.00 ± 59.68

0.252

After CRT

 Total Leukocytes (× 103 µl)

8.3 ± 1.8

8.1 ± 1.5

8.6 ± 2.1

0.220

 LVEF (%)

33.9 ± 10.8

39.1 ± 9.8

27.6 ± 8.4

0.001

 LVESV (mL)

151.4 ± 96.0

100.4 ± 36.7

215.1 ± 109.6

 < 0.001

 LVEDV (mL)

220.2 ± 108.5

168.9 ± 50.3

284.4 ± 127.9

0.001

 hsCRP (mg/L)

4.1 ± 4.6

2.6 ± 1.8

6.2 ± 6.4

0.288

 BNP (pg/mL)

245.3 ± 334.6

139.6 ± 164.1

403.9 ± 456.0

0.043

  1. Bold: Statistically significant differences (P < 0.05)
  2. NYHA New York Heart Association, L Lateral, PL posterolateral, A anterior, AL anterolateral, LVEF left ventricular ejection fraction, LVESV left ventricular end-systolic volume, LVEDV left ventricular end-diastolic volume, hsCRP high sensitivity C-reactive protein, BNP B-type natriuretic peptide, HDL Cholesterol high-density lipoprotein cholesterol, LDL Cholesterol low-density lipoprotein cholesterol