PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis

Table 1 Main characteristics of studies included in the meta-analysis of the relationship between SNP rs918592 and the risk of ischemic stroke

First author	Year	Ethnicity	Sample size		Mean age ± SD(year)		Genotyping method	Matching variables of controls	Phenotype
First author	Year	Ethnicity	Cases	Controls	Cases	Controls	Genotyping method	Matching variables of controls	Phenotype
Tang JS	2007	Chinese Han	131	112	62.4 ± 9.63	53.2 ± 7.98	PCR–RFLP	Age, gender, smoking, drinking, and BMI	IS
Xu SL	2008	Chinese Han	116	110	65.9 ± 12.4	65.1 ± 12.7	PCR–RFLP	Age and gender	LAA and SVD
He Y	2012	Chinese Han	400	400	61 ± 10	58 ± 10	PCR–RFLP	Age and gender	IS
He Y	2013	Chinese Han	186	232	36.5 ± 6.4	36.8 ± 6.8	PCR–RFLP	Age and gender	early onset IS
Ma JH	2013	Chinese Han	395	395	59.78 ± 11.55		SNaPshot	Age and gender	IS
Ma J	2014	Chinese Han	189	194			PCR–RFLP	Age and gender	IS
Song HJ	2015	Chinese Han	307	227	61.86 ± 8.77	63.35 ± 7.92	SNaPshot	Age, gender, MAP, smoking, HDL, LDL, BMI, and FG	IS with hypertension
Ma JH	2013	Chinese Uyghur	395	395	58.65 ± 10.46		SNaPshot	Age and gender	IS
Ma J	2014	Chinese Uyghur	184	183			PCR–RFLP	Age and gender	IS
Xu MC	2014	Chinese Wa	52	55	59.00 ± 7.75	56.64 ± 8.29	PCR–RFLP and Sanger sequencing	Age, gender, smoking, and diabetes	IS

PCR–RFLP polymerase chain reaction-restriction fragment length polymorphism, BMI body mass index, MAP mean arterial pressure, HDL high density lipoprotein, LDL low density lipoprotein, FG fasting glucose, IS ischemic stroke, LAA large artery atherosclerosis, SVD cerebral small vessel disease

ISSN: 1471-2261