Table 3 GRADE evidence profile
Certainty assessment | Summary of findings | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Participants (studies) Follow-up | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Overall certainty of evidence | Study event rates (%) | Relative effect (95% CI) | Anticipated absolute effects | ||
With Standard of Care | With VA-ECMO | Risk with Standard of Care | Risk difference with VA-ECMO | ||||||||
30-day mortality | |||||||||||
611 (4 RCTs) | not serious | not serious | not serious | seriousa | none | ⨁⨁⨁◯ Moderate | 148/306 (48.4%) | 140/305 (45.9%) | RR 0.96 (0.81 to 1.13) | 484 per 1,000 | 19 fewer per 1,000 (from 92 fewer to 63 more) |
30-day reinfarct | |||||||||||
491 (3 RCTs) | not serious | not serious | not serious | very seriousb | none | ⨁⨁◯◯ Low | 5/247 (2.0%) | 4/244 (1.6%) | RR 0.95 (0.25 to 3.60) | 20 per 1,000 | 1 fewer per 1,000 (from 15 fewer to 53 more) |
Stroke | |||||||||||
608 (4 RCTs) | not serious | not serious | not serious | very seriousb | none | ⨁⨁◯◯ Low | 11/306 (3.6%) | 12/302 (4.0%) | RR 1.16 (0.38 to 3.57) | 36 per 1,000 | 6 more per 1,000 (from 22 fewer to 92 more) |
Acute kidney injury/Renal Replacement Therapy | |||||||||||
566 (3 RCTs) | not serious | not serious | not serious | very seriousb | none | ⨁⨁◯◯ Low | 40/285 (14.0%) | 25/281 (8.9%) | RR 0.65 (0.41 to 1.03) | 140 per 1,000 | 49 fewer per 1,000 (from 83 fewer to 4 more) |
Bleeding events | |||||||||||
608 (4 RCTs) | not serious | not serious | not serious | seriousa | none | ⨁⨁⨁◯ Moderate | 36/306 (11.8%) | 76/302 (25.2%) | RR 2.07 (1.44 to 2.97) | 118 per 1,000 | 126 more per 1,000 (from 52 more to 232 more) |
Sepsis | |||||||||||
611 (4 RCTs) | not serious | not serious | not serious | very seriousb | none | ⨁⨁◯◯ Low | 51/306 (16.7%) | 54/305 (17.7%) | RR 1.06 (0.77 to 1.47) | 167 per 1,000 | 10 more per 1,000 (from 38 fewer to 78 more) |
Pneumonia | |||||||||||
152 (2 RCTs) | not serious | not serious | not serious | extremely seriousb | none | ⨁◯◯◯ Very low | 19/77 (24.7%) | 18/75 (24.0%) | RR 0.99 (0.58 to 1.68) | 247 per 1,000 | 2 fewer per 1,000 (from 104 fewer to 168 more) |