Table 3 Evidence overview – aortic surgery
From: The role of hemoadsorption in cardiac surgery – a systematic review
No | Study | Study design | Device | Interventions | Controls | Results of the intervention |
|---|---|---|---|---|---|---|
1 | 2019 Saller, T., et al. [25] | Retrospective Case–control (PSM) Procedure: Aortic surgery with hypothermic circulatory arrest | CytoSorb® (intra-op on CPB) | 168 | 168 | Significantly: - lower requirement for intraoperative norepinephrine - less pRBC & FFP transfusions - higher requirement for PCC Notably: - improved acid–base balance - lower intraoperative mortality |
2 | 2021 Mehta, Y., et al. [26] | Retrospective Case–control Procedure: Ascending aorta replacement | CytoSorb® (intra-op on CPB) | 8 | 8 | Significantly: - lower IL-6 (primary outcome) - requirement for norepinephrine - ICU and hospital stay Notably: - improved PaO2/FiO2 ratio - duration of mechanical ventilation No significant differences in primary outcomes PCT, WBC count, and CRP |
3 | 2023 Doukas, P., et al | Prospective RCT Procedure: Thoracoabdominal aortic repair | CytoSorb® (intra-op on CPB) | 10 | 17 | Significantly: - lower incidence of severe ARDS Notably: - shorter duration of mechanical ventilation |