Fig. 7
From: Effect of NLRP3 gene knockdown on pyroptosis and ferroptosis in diabetic cardiomyopathy injury
Promotion of mitochondrial ROS production abolishes the protective effect of NLRP3 knockdown. (A) Representative blots in H9C2 cardiac cells. The protein levels of NLRP3 (B), GSDMD-NT (C), IL-1β (D), IL-18 (E), GPX4 (F) and xCT (G) in H9C2 cardiac cells normalized by GAPDH levels. H. Changes of LDH levels in cell supernatant of each group.(mean ± SD, n = 3). *P < 0.05, **P < 0.01 vs. CON; ##P < 0.01 vs. HG; ^P < 0.05, ^^P < 0.01 vs. HG + sh-NLRP3