Fig. 8
From: Effect of NLRP3 gene knockdown on pyroptosis and ferroptosis in diabetic cardiomyopathy injury
Inhibition of NLRP3 suppressed DM or high glucose-induced H9C2 cardiac cell injury through inhibiting NLRP3 inflammasome mediated pyroptosis and GPX4 mediated ferroptosis. NLRP3: The NACHT-, LRR- and PYD domains-containing protein 3 (NLRP3), GSDMD: Gasdermin D, GPX4: glutathione peroxidase 4, GSH: glutathione,
PLOO: phospholipid, Cys: cystine, Glu: glutamate