Table 3 Allele frequencies and genotype frequencies of SNPs in CD247 gene among DCM patients and controls and their association with DCM risk
From: Polymorphisms of CD247 gene is associated with dilated cardiomyopathy in Chinese Han population
SNP | Patients n = 355(46.77%) | Controls n = 404(53.23%) | OR (95%CI) | p value | |
|---|---|---|---|---|---|
rs12141731 | Allele | ||||
C | 374(0.53) | 421(0.52) | 0.977(0.799–1.196) | 0.824 | |
T | 336(0.47) | 387(0.48) | |||
Genotype | |||||
C/C | 94 (26.5%) | 105 (26%) | 1.00 | ||
Codominant | C/T | 186 (52.4%) | 211 (52.2%) | 1.02 (0.72–1.43) | 0.97 |
T/T | 75 (21.1%) | 88 (21.8%) | 1.05 (0.69–1.59) | ||
Dominant | C/C | 94 (26.5%) | 105 (26%) | 1.00 | |
C/T-T/T | 261 (73.5%) | 299 (74%) | 1.03 (0.74–1.42) | 0.88 | |
Recessive | C/C-C/T | 280 (78.9%) | 316 (78.2%) | 1.00 | |
T/T | 75 (21.1%) | 88 (21.8%) | 1.04 (0.73–1.47) | 0.83 | |
Overdominant | C/C-T/T | 169 (47.6%) | 193 (47.8%) | 1.00 | |
C/T | 186 (52.4%) | 211 (52.2%) | 0.99 (0.75–1.32) | 0.9 | |
rs858543 | Allele | ||||
T | 357(0.5) | 472(0.58) | 0.72(0.588–0.882) | 0.001 | |
C | 353(0.5) | 336(0.42) | |||
Genotype | |||||
T/T | 87 (24.5%) | 133 (32.9%) | 1.00 | ||
Codominant | C/T | 183 (51.5%) | 206 (51%) | 0.74 (0.53–1.03) | 0.0051 |
C/C | 85 (23.9%) | 65 (16.1%) | 0.50 (0.33–0.76) | ||
Dominant | T/T | 87 (24.5%) | 133 (32.9%) | 1.00 | |
C/T-C/C | 268 (75.5%) | 271 (67.1%) | 0.66 (0.48–0.91) | 0.01 | |
Recessive | T/T-C/T | 270 (76.1%) | 339 (83.9%) | 1.00 | |
C/C | 85 (23.9%) | 65 (16.1%) | 0.61 (0.42–0.87) | 0.0067 | |
Overdominant | T/T-C/C | 172 (48.5%) | 198 (49%) | 1.00 | |
C/T | 183 (51.5%) | 206 (51%) | 0.98 (0.74–1.30) | 0.88 |