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Fig. 3 | BMC Cardiovascular Disorders

Fig. 3

From: Exosomes activate hippocampal microglia in atrial fibrillation through long-distance heart–brain communication

Fig. 3

Ad-CD63-RFP-labelled canine EAT exosomes penetrate the BBB. (A, B) Fluorescence mean intensity of Ad-CD63-RFP in the hippocampus of the three groups of canines. (C) Fluorescence mean intensity of Ad-CD63-RFP in different parts of brain tissue. (D) bEnd.3 cells mimic the BBB, exosomes isolated from the EAT of canines penetrate the BBB, and red fluorescence indicates Ad-CD63-RFP-labelled exosomes. *** P < 0.001 versus the sham group; ### P < 0.001 versus the pacing group; **** P < 0.0001 versus the control group. EAT = epicardial adipose tissue; Ad = adenovirus; BBB = blood brain barrier

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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