Table 1 Patients characteristics and postoperative outcomes in pre- subgroup treatment
Variables | Sivelestat (N = 95) | Control (n = 92) | P value |
|---|---|---|---|
Basic characteristics | |||
Age (year) | 52.47 ± 11.4 | 50.99 ± 11.3 | 0.37 |
Gender (n, %)# | 68, 71.58% | 65, 70.65% | 0.89 |
BMI (kg/m²) | 24.89 ± 3.35 | 25.42 ± 3.89 | 0.33 |
LVEF (%) | 53.62 ± 7.48 | 53.28 ± 7.31 | 0.67 |
Disease history (n, %) | |||
Diabetes | 6, 5.26% | 5, 5.43% | 0.79 |
Hypertension | 62, 65.26% | 69, 75.00% | 0.18 |
CKD | 14, 14.74% | 23, 25.00% | 0.08 |
CLD | 7, 7.37% | 6, 6.52% | 0.82 |
TCO | |||
CPB (min) | 201.00 (172.00,240.00) | 212.50 (186.50,245.75) | 0.17 |
OT(min) | 423.08 ± 105.71 | 418.93 ± 86.75 | 0.77 |
CAT (℃) | 26.10 (25.50,26.90) | 26.100 (25.60,26.70) | 0.49 |
Primary outcomes (n, %) | |||
30-day mortality | 22, 23.16% | 17, 18.48% | 0.43 |
ECMO use | 3, 3.16% | 4, 4.35% | 0.67 |
IABP use | 0 | 0 | —— |
CRRT use | 17, 17.89% | 19, 20.65% | 0.63 |
Secondary outcomes (n, %) | |||
Pneumonia | 3, 3.15% | 2, 2.17% | 1.00 |
High arterial lactic > 48 h | 58, 61.05% | 48, 52.17% | 0.53 |
Length of ICU stay (days) | 4.00 (3.00, 7.00) | 4.00 (3.00, 6.75) | 0.84 |
MV time (hours) | 22.00 (15.00, 60.00) | 19.00 (14.00, 54.00) | 0.48 |
SMV | 23, 24.21% | 18, 19.57% | 0.44 |
Postoperative thoracic drainage (ml) | 1215.00 (953.75, 1675.00) | 1225.00 (835.00, 1920.00) | 0.96 |
Length of stay (d) | 14.00 (11.00, 18.00) | 12.00 (11.00, 18.75) | 0.34 |