Table 3 Comparison of baseline characteristics and postoperative outcomes between sivelestat group and control group patients with normal, mild, and moderate lung injury
Variables | Moderate | Mild | Normal | ||||||
|---|---|---|---|---|---|---|---|---|---|
Sivelestat (n = 19) | Control (n = 24) | P value | Sivelestat (n = 32) | Control (n = 34) | P value | Sivelestat (n = 44) | Control (n = 34) | P value | |
Basic characteristics | |||||||||
Age (year) | 53.95 ± 10.98 | 52.33 ± 10.99 | 0.64 | 54.00 ± 8.40 | 51.24 ± 12.51 | 0.30 | 50.75 ± 13.09 | 49.79 ± 10.54 | 0.72 |
Gender (n,%)# | 12, 63.16% | 16, 66.67% | 0.81 | 25, 78.13% | 22, 64.71% | 0.23 | 31, 70.45% | 27, 79.41% | 0.27 |
BMI (kg/m²) | 25.59 ± 4.07 | 25.59 ± 4.27 | 1.00 | 25.83 ± 2.63 | 25.14 ± 4.34 | 0.44 | 24.48 ± 3.27 | 25.57 ± 3.18 | 0.14 |
LVEF (%) | 51.42 ± 5.94 | 54.04 ± 7.14 | 0.21 | 52.33 ± 7.55 | 52.00 ± 5.67 | 0.84 | 52.52 ± 6.94 | 55.06 ± 4.53 | 0.07 |
History (n,%) | |||||||||
Diabetes | 2, 10.53% | 3, 12.50% | 1.00 | 1, 3.13% | 1, 2.94% | 0.97 | 3, 6.82% | 1, 2.94% | 0.80 |
Hypertension | 12, 63.16% | 18, 75.00% | 0.40 | 21, 65.63% | 25, 73.53% | 0.49 | 29, 65.91% | 26, 76.47% | 0.31 |
CKD | 3, 15.79% | 5, 20.83% | 0.98 | 3, 9.38% | 8, 23.53% | 0.12 | 8, 18.18% | 10, 29.41% | 0.24 |
CLD | 4, 21.05% | 0, 0.00% | 0.67 | 3, 9.38% | 3, 8.82% | 0.94 | 0, 0.00% | 3, 8.82% | 0.16 |
TCO (n,%) | |||||||||
CPB (min) | 224.84.28 ± 65.62 | 212.96 ± 44.011 | 0.49 | 205.93 ± 44.05 | 210.32 ± 40.16 | 0.68 | 206.43 ± 71.82 | 234.35 ± 89.73 | 0.13 |
OT (min) | 448.89 ± 111.14 | 407.92 ± 79.40 | 0.17 | 417.93 ± 86.94 | 409.91 ± 81.15 | 0.70 | 425.07 ± 118.17 | 434.85 ± 97.86 | 0.70 |
CAT (℃) | 26.46 ± 1.13 | 26.54 ± 1.35 | 0.84 | 26.13 ± 0.93 | 26.16 ± 1.12 | 0.89 | 26.86 ± 2.39 | 26.26 ± 1.79 | 0.22 |
Primary outcomes (n,%) | |||||||||
30-day mortality | 3, 15.80% | 3, 12.50% | 0.75 | 6, 18.80% | 7, 20.60% | 0.85 | 12, 27.20% | 7, 20.60% | 0.49 |
ECMO use | 0, 0.00% | 0.00% | —— | 1, 3.13% | 2, 5.88% | 0.60 | 2, 4.55% | 2, 5.88% | 0.81 |
IABP use | 0 | 0 | —— | 0 | 0 | —— | 0 | 0 | —— |
CRRT use | 4, 21.10% | 8, 33.30% | 0.37 | 7, 21.87% | 5, 14.71% | 0.45 | 6, 13.64% | 6, 17.65% | 0.63 |
Secondary outcomes (n,%) | |||||||||
Pneumonia | 1, 5.26% | 1, 4.17% | 0.36 | 2, 6.25% | 0, 0.00% | 0.45 | 0, 0.00% | 1, 2.94% | 0.89 |
High arterial lactic > 48 h | 12, 63.16% | 16, 66.67% | 0.81 | 20, 62.50% | 20, 58.82% | 0.76 | 24, 54.55% | 14, 41.18% | 0.24 |
Length of ICU stay (days) | 6.00 (4.00, 8.75) | 4.50 (3.00, 10.50) | 0.59 | 4.00 (3.00, 7.25) | 5.00 (3.00, 7.50) | 0.53 | 4.00 (3.00, 7.00) | 4.00 (2.00, 5.00) | 0.27 |
MV time (hours) | 40.00 (17.25, 68.25) | 24.50 (15.25, 79.50) | 0.76 | 37.00 (17.75, 62.25) | 19.50 (14.00, 65.50) | 0.25 | 20.50 (14.00, 45.25) | 17.50 (14.00, 38.00) | 0.42 |
SMA | 4, 21.10% | 3, 12.50% | 0.74 | 9, 28.13% | 8, 23.53% | 0.89 | 11, 25.00% | 6, 17.65% | 0.44 |
Postoperative thoracic drainage (ml) | 1060.00 (887.50, 1475.00) | 1375.00 (842.50, 2283.75) | 0.34 | 1485.00 (995.00, 1795.00) | 1355.00 (992.50, 1407.50) | 0.85 | 1270.00 (985.00, 1687.50) | 1076.00 (622.50, 1700.00) | 0.28 |
Length of stay (d) | 13.50 (10.75, 16.25) | 12.00 (11.00, 21.25) | 0.95 | 14.00 (12.00, 17.50) | 12.50 (11.00, 19.25) | 0.40 | 13.00 (10.00, 19.00) | 12.00 (9.00, 16.25) | 0.21 |