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Table 4 Risk of bias assessment of included studies

From: Invasive versus conservative strategies for non-ST-elevation acute coronary syndrome in the elderly: an updated systematic review and meta-analysis of randomized controlled trials

RCT Name

D1

D2

D3

D4

D5

Overall Risk

FRISC II [34]

Low

Some concerns

Low

Low

Low

Low

RITA 3 [35]

Low

Some concerns

Low

Low

Low

Low

TACTICS–TIMI 18 [9]

Low

Some concerns

Low

Low

Low

Low

ICTUS [36]

Low

Some concerns

Low

Low

Low

Low

Italian Elderly ACS [31]

Low

Some concerns

Low

Low

Low

Low

MOSCA [30]

Low

Some concerns

Low

Low

Low

Low

After Eighty [21, 33]

Low

Some concerns

Low

Low

Low

Low

80 + study [29]

Low

Some concerns

Low

Low

Low

Low

RINCAL [28]

Low

Some concerns

Low

Low

Low

Low

MOSCA-FRAIL [20, 32]

Low

Some concerns

Low

Low

Low

Low

SENIOR-RITA [26]

Low

Some concerns

Low

Low

Low

Low

  1. Bias Domains:
  2. D1: bias arising from the randomization process
  3. D2: bias due to deviations from intended interventions
  4. D3: bias due to missing outcome data
  5. D4: bias in the measurement of the outcome
  6. D5: bias in the selection of the reported result