Efficacy and safety of adenosine for supraventricular tachycardia: A meta-analysis utilizing BioMedGPT-LM-7B

Table 2 Summary of findings for the main comparison of the effects of adenosine/atp versus calcium channel antagonists for supraventricular tachycardia

Outcomes	Number of participants	Number of studies	Odds ratio (95% CI)	Follow-up	Quality of the evidence (GRADE)*	What happens
Odds of reversion	960	10 RCTs	1.44 [0.89, 2.34]	Until reversion occurred or the predetermined maximum dose was reached	Moderate^a	Higher odds of reversion indicate better effect
Major adverse event: hypotension	438	5 RCTs	3.07 [0.47, 19.85]	Up to 2 h after infusion	Low^{a, b}	A lower hypotension rate indicates fewer adverse events

*GRADE Working Group grades of evidence
High quality: We are very confident that the true effect is close to the estimated effect.
Moderate quality: We are moderately confident in the effect estimate. The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect.
Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.
^a Quality of the evidence downgraded by one level for imprecision. Moderate to wide confidence intervals.
^bQuality of the evidence downgraded by one level for study limitations. There was a high risk of bias in all studies, as none of the studies were blinded.

ISSN: 1471-2261