Fig. 1

Identification of 12 DEcircRNAs upregulated in AD samples in comparison to AA and the control samples. (A). Volcano plots showing the differentially expressed circRNAs (DEcircRNAs) among AA vs. control, AD vs. control and AD vs. AA groups. (B). Venn diagram of the interaction of DEcircRNAs among AA vs. control, AD vs. control and AD vs. AA pairs. (C). List of 12 DEcircRNAs being upregulated in AD samples in comparison to AA samples. (D). Heatmap displaying the relative expression levels of 12 DEcircRNAs in the control, AA and AD samples. (E) qRT-PCR validation of DEcircRNA expressions in the control, AA and AD samples (n = 4 in each group). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001