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Table 1 Baseline characteristics of the included studies

From: The role of bariatric surgery in hypertension control: a systematic review and meta-analysis with extended benefits on metabolic factors

NUM

Study ID

Country

Group

N, group

Follow-up

(months)

Age

(years)

(mean ± Sd)

Female %

BMI

(kg/m²)

(mean ± Sd)

Body

Weight

(kg)

(mean ± Sd)

Waist Circumference (cm)

(mean ± Sd)

SBP

(mmHg)

(mean ± Sd)

DBP

(mmHg)

(mean ± Sd)

HT rate (%)

DM rate (%)

FBS

(mg/mL)

(mean ± Sd)

HbA1c

(%)

(mean ± Sd)

LDL Cholesterol (mg/dL)

(mean ± Sd)

HDL Cholesterol (mg/dL)

(mean ± Sd)

Total Cholesterol (mg/dL)

(mean ± Sd)

Triglycerides (mg/dL)

(mean ± Sd)

1

F. R. Azevedo, (2018)

Brazil

SG + TB

Plus SMT

10

24

45 ± 10

NA

33.4 ± 2.6

102.2 ± 12.2

112 ± 8

NA

NA

90%

100%

217 ± 103

9.3 ± 2.1

86 ± 17

33 ± 8

183 ± 45

369 ± 25

SMT

10

24

56 ± 7

NA

30.3 ± 2.1

88.5 ± 11.7

106 ± 6

NA

NA

100%

100%

145 ± 71

8 ± 1.5

95 ± 33

41 ± 10

172 ± 45

202 ± 185

2

A. P. Courcoulas,

(2020)

America

RYGB + LLLI

20

60

45.4 ± 7.5

80%

35.7 ± 2.7

99.3 ± 13.4

110.6 ± 8.2

139.7 ± 12.3

81.3 ± 9.6

50%

100%

191.5 ± 82

8.6 ± 2.1

124.3 ± 3.8

41.8 ± 8.7

200.2 ± 40.3

169.7 ± 27.16

LAGB + LLLI

21

60

47.7 ± 7

80.9%

35.6 ± 3.4

100.2 ± 14

114.5 ± 11.9

134.5 ± 17

77.1 ± 8.6

61.9%

100%

180 ± 85.4

7.9 ± 2.2

107.4 ± 29.7

40 ± 9.3

189.5 ± 5.8

221.9 ± 44.4

ILWLI

20

60

48.9 ± 4.7

85%

35.7 ± 3.3

102 ± 14.3

118 ± 9.5

132 ± 17.9

76.3 ± 9.6

65%

100%

142.1 ± 28

7 ± 0.8

105.5 ± 33.3

44.1 ± 17.1

182 ± 39

161.2 ± 24.52

3

Abu Dayyeh, B.K.,

(2022)

America

ESG + LSM

77

13

47.3 ± 9.3

88%

35.5 ± 2.6

98.4 ± 12.3

110.3 ± 10.4

134.2 ± 15.2

82.4 ± 9.3

49%

23%

101.7 ± 26.4

5.8 ± 0.8

115.0 ± 37.3

54.5 ± 15.5

193.8 ± 41.0

120.8 ± 63.1

LSM

110

13

45.7 ± 10

83%

35.7 ± 2.6

99.1 ± 12.8

109.7 ± 12.5

131.6 ± 15.2

80.9 ± 11.2

52.7%

32%

98.6 ± 28.4

5.8 ± 0.8

111.9 ± 31.8

54.9 ± 14

192 ± 37.3

123.3 ± 51.5

4

David E. Cummings

(2016)

America

RYGB

15

12

52 ± 8.3

80%

38 ± 3.7

108.8 ± 14.9

121.7 ± 10.2

129.3 ± 20.6

77 ± 10.2

80%

NA

145.8 ± 46.8

7.7 ± 1

92.8 ± 27.7

42.54 ± 11.6

166.28 ± 38.67

150.58 ± 62

Intensive lifestyle and medical intervention

17

12

54.6 ± 6.3

58%

37.1 ± 3.5

112.8 ± 16.5

120.8 ± 10

120.1 ± 9.6

74.8 ± 7.5

94%

NA

153 ± 46.8

7.3 ± 0.9

85.07 ± 23.2

42.54 ± 7.734

170.15 ± 30.936

203.7 ± 132.86

5

J. B. Dixon,

(2008)

Australia

LAGB + conventional diabetes care

30

24

46.6 ± 7.4

50%

37 ± 2.7

105.6 ± 13.8

114.1 ± 10.2

136.4 ± 15.6

86.6 ± 9.4

93%

NA

156.7 ± 38.5

7.8 ± 1.2

NA

47.1 ± 10.1

201.8 ± 32.7

190.6 ± 106.6

Conventional diabetes therapy with a focus on weight loss by lifestyle change

30

24

47.1 ± 8.7

56%

37.2 ± 2.5

105.9 ± 14.2

116 ± 10

135.3 ± 14.4

84.5 ± 9.8

90%

NA

158 ± 48.7

7.6 ± 1.4

NA

48.1 ± 11.1

198.2 ± 56.7

188.7 ± 111.8

6

J. B. Dixon,

(2012)

Australia

LAGB

30

24

47.4 ± 8.8

43%

46.3 ± 6

134.9 ± 22.1

136.1 ± 13.1

137.6 ± 18.7

83.1 ± 8.2

50%

41%

107.4 ± 30.6

6.25 ± 1.1

NA

44.8 ± 10.4

194.4 ± 42.2

163.7 ± 83.1

conventional weight loss

30

24

50 ± 8.2

40%

43.8 ± 4.9

126 ± 19.3

126.6 ± 13.1

142.2 ± 16.9

86.8 ± 8.8

56%

33%

103.7 ± 23.5

6.26 ± 1.1

NA

43.6 ± 10.4

192.2 ± 36.1

195.6 ± 96.9

7

F. Halperin,

(2014)

America

RYGB

19

12

50.7 ± 7.6

68%

36 ± 3.5

104.6 ± 15.5

117.8 ± 14.9

132.8 ± 10.5

81.7 ± 7.4

NA

100%

132.3 ± 49.7

8.24 ± 1.42

88.1 ± 27.7

43.6 ± 9.7

154.2 ± 34

120 ± 66

intensive lifestyle and medical

management

(WhyWAIT)

19

12

52.6 ± 4.3

52%

36.5 ± 3.4

102.7 ± 17

114.1 ± 12.2

126.3 ± 14.7

76.6 ± 8.8

NA

100%

162.2 ± 53.8

8.83 ± 1.01

98.9 ± 29.3

39.1 ± 9.9

162.5 ± 38.6

156 ± 76

8

P. Koehestanie,

(2014)

Netherlands

Endoscopic DJBL + dietary intervention

38

12

49.5 ± 12.3

34%

34.6 ± 4.3

105.4 ± 13.7

NA

147 ± 13

92 ± 10.7

NA

100%

198.2 ± 49.9

8.3 ± 1

88.9 ± 35.7

42.5 ± 14.8

170.1 ± 32.5

150.6 ± 136.3

dietary intervention

39

12

49 ± 8.4

35%

36.8 ± 7.2

110.8 ± 22.5

NA

152 ± 16.9

90 ± 10.7

NA

100%

198.2 ± 52.6

8.3 ± 1

92.8 ± 35.7

46.4 ± 11.9

170.1 ± 50.6

177.1 ± 109

9

Z. Liang

(2013)

China

RYGB

31

12

50.8 ± 5.4

29%

30.5 ± 0.9

82 ± 3.5

NA

160.8 ± 7.8

88.6 ± 5.5

NA

NA

169.4 ± 20.9

10.5 ± 1.2

148.5 ± 24.4

34.4 ± 6.6

201.5 ± 21.3

300.3 ± 104.5

usual care with Exenatide therapy

34

12

50.9 ± 5.9

29%

30.3 ± 1.4

81.8 ± 3.7

NA

159.9 ± 8.6

85.8 ± 11

NA

NA

168.6 ± 23.1

10.5 ± 1.5

143.9 ± 24.7

34.8 ± 5

205.3 ± 35.6

315.3 ± 95.7

usual care without Exenatide therapy

36

12

51.8 ± 6.7

33%

30.3 ± 2

81.3 ± 5

NA

156.6 ± 11.8

87.8 ± 6.8

NA

NA

169.2 ± 25.9

10.9 ± 1.4

143.9 ± 16.2

34 ± 5.8

194.5 ± 39.4

309.1 ± 116.9

10

G. Mingrone,

(2021)

Italy

RYGB

120

20

43.9 ± 7.6

10%

44.2 ± 5.2

128.7 ± 21.3

129 ± 14.9

145.8 ± 20.5

91.5 ± 14.2

NA

NA

171.2 ± 59.5

8.6 ± 1.4

108.3 ± 34.8

42.5 ± 7.7

177.9 ± 38.7

150.6 ± 79.7

BPD

120

20

43.6 ± 8.2

8%

44.4 ± 9

128 ± 28.7

139.5 ± 22.3

154.5 ± 29.7

95.9 ± 12.9

NA

NA

174.8 ± 61.3

8.9 ± 1.7

135.3 ± 50.3

38.7 ± 7.7

212.7 ± 58

194.9 ± 79.7

medical therapy plus lifestyle interventions

120

20

43.5 ± 7.3

8%

44.6 ± 5.7

137 ± 19

127 ± 13.8

155.2 ± 34.2

96 ± 17.5

NA

NA

178.4 ± 61.3

8.5 ± 1.2

154.7 ± 54.1

38.7 ± 7.7

235.9 ± 61.9

221.4 ± 70.9

11

Nordstrand N, et al. (2012)

Norway

RYGB

49

12

44.4 ± 9.5

67%

45/5 ± 5/5

134 ± 22

NA

150 ± 18

83 ± 10

NA

28%

NA

NA

NA

NA

NA

NA

ILI

41

12

47.5 ± 10.6

70%

42/3 ± 4

122 ± 14

NA

146 ± 20

79 ± 9

NA

31%

NA

NA

NA

NA

NA

NA

12

Tur JJ, et al. (2013)

Spain

BPD

37

12

44.1 ± 9.8

70%

49.2 ± 5.9

132/8 ± 24.4

NA

132.6 ± 14.4

82.8 ± 8.9

NA

24%

110.4 ± 26.9

6.3 ± 0.8

118 ± 28.9

40.2 ± 6.2

178.8 ± 38

136.5 ± 63.9

COT

46

12

46.7 ± 10.3

63%

46.8 ± 4.6

126 ± 17.9

NA

136.1 ± 14

86.6 ± 10

NA

23%

116.4 ± 40.6

7.8 ± 1.7

119.2 ± 23

44.1 ± 9.1

194.4 ± 31.8

151.4 ± 66.7

ILI

60

12

47.8 ± 11.5

71%

45.8 ± 5

122.2 ± 20.1

NA

131.9 ± 18.7

86.8 ± 10

NA

25%

122.1 ± 40.1

6.7 ± 1.7

121.8 ± 31.8

49.4 ± 10.4

202.8 ± 37.2

162.1 ± 62.4

13

Wentworth JM, et al. (2014)

Australia

LAGB + MDC

25

24

53 ± 6

76%

29 ± 1

81 ± 10

NA

130 ± 18

83 ± 10

NA

NA

133.3 ± 37.8

6.9 ± 1.2

NA

47.9 ± 15.2

187.2 ± 46

135 ± 99

MDC

26

24

53 ± 7

65%

29 ± 1

83 ± 12

NA

131 ± 11

84 ± 9

NA

NA

147.7 ± 41.4

7.2 ± 1.1

NA

44 ± 15.2

195 ± 61.6

164.7 ± 49.5

14

Xiang AH, et al. (2018)

USA

gastric banding

44

24

47 ± 10

77%

35.7 ± 2.9

97.5 ± 12.2

NA

127.1 ± 10.5

78.3 ± 7.5

NA

43%

111.7 ± 12.6

5.9 ± 2.6

104.4 ± 27.1

46.4 ± 11.6

174 ± 27.1

116.9 ± 137.55

metformin

44

24

51 ± 9

79%

35 ± 2.9

96.1 ± 10.9

NA

126.4 ± 10

75.9 ± 8.1

NA

40%

111.7 ± 14.4

5.8 ± 2.6

104.4 ± 30.9

46.4 ± 11.6

174 ± 34.8

108.9 ± 158.2

15

Ikramudin et al. (2015)

USA

Roux-en-Y

60

24

49 ± 9

63%

34.9 ± 3

NA

114 ± 10

127 ± 15

78 ± 12

70%

100%

205.2 ± 52.2

9.6 ± 1

104.4 ± 35

42.5 ± 1

181.7 ± 39

186.3 ± 79.8

intensive lifestyle and medical management

59

24

49 ± 8

57%

34.3 ± 3

NA

113 ± 12

132 ± 14

79 ± 10

69%

100%

214.2 ± 57.6

9.6 ± 1

104.4 ± 43

42.5 ± 8

189.5 ± 46

194.1 ± 79.8

16

Ikramudin et al. (2013)

USA

Roux-en-Y

60

12

49 ± 9

63%

34.9 ± 3

98.8 ± 3.6

114 ± 10

127 ± 15

78 ± 12

70%

100%

222 ± 73.5

9.6 ± 1

104.4 ± 35

42.5 ± 1

181.7 ± 39

186.3 ± 1

Medical management

60

12

49 ± 8

56%

34.3 ± 3

97.9 ± 4.2

113 ± 12

132 ± 14

79 ± 10

68%

98%

207 ± 56.1

9.6 ± 1

104.4 ± 43

42.5 ± 8

189.5 ± 46

194.1 ± 1

17

Ikramudin et al. (2018)

USA

Roux-en-Y

55

60

49 ± 9

67%

34.9 ± 3

98 ± 17

114 ± 10

127 ± 15

78 ± 12

NA

NA

222 ± 75

9.6 ± 1

102 ± 35

41 ± 11

181 ± 38

200 ± 105

Medical management

43

60

48 ± 8

72%

34.4 ± 3

99 ± 14

113 ± 12

132 ± 14

79 ± 10

NA

NA

205 ± 54

9.6 ± 1

102 ± 41

41 ± 8

186 ± 42

211 ± 112

18

Schavion et al. (2018)

Brazil

Roux-en-Y + Medical management

50

12

43 ± 9

72%

37.4 ± 2

102 ± 14

112.2 ± 8

123 ± 12

77.6 ± 7

100%

8%

99.8 ± 18

5.7 ± 1

121.5 ± 30

46.4 ± 15

NA

166.8 ± 104.8

Medical management

50

12

45 ± 9

68%

36.4 ± 3

100.1 ± 14

111 ± 9

122.8 ± 13

78 ± 9

100%

8%

99.7 ± 20

5.7 ± 1

120.8 ± 35

48.3 ± 13

NA

154.7 ± 68

19

Simonson (2019)

USA

LAGB

18

36

51 ± 12.7

50%

36.4 ± 3

106.8 ± 10.4

115.9 ± 7.1

128.5 ± 7.4

79.1 ± 5.3

NA

NA

167.4 ± 63.8

8.41 ± 1.1

92.3 ± 26.6

36.7 ± 9.4

155.3 ± 33.9

175.9 ± 119.3

Control

22

36

51.6 ± 7.5

40%

36.7 ± 4.2

111.6 ± 17.9

114.4 ± 9.4

126.2 ± 13

80.9 ± 8.1

NA

NA

154.7 ± 47.8

8.08 ± 1.23

91.5 ± 26.6

42 ± 12

160.6 ± 28.6

145.1 ± 104.3

20

Schiavon (2019)

Brazil

RYGB

50

12

43.1 ± 9.2

82%

37.4 ± 2.4

102 ± 13.6

NA

126 ± 40.2

106.4 ± 25

100%

8%

NA

NA

NA

NA

NA

NA

Control

50

12

44.6 ± 9.2

70%

36.4 ± 2.9

100.1 ± 14

NA

124.6 ± 28.1

108.6 ± 25.6

100%

8%

NA

NA

NA

NA

NA

NA

21

Schiavon (2024)

Brazil

RYGB

50

60

43.6 ± 9.2

60%

37.3 ± 3.67

101.95 ± 14.44

112.23 ± 10.47

122.98 ± 15.75

77.6 ± 10.83

100%

6%

98.36 ± 19.66

5.7 ± 0.72

119.1 ± 43.9

45.01 ± 14.01

NA

154.56 ± 80.2

Control

50

60

45.6 ± 8.5

46%

36.4 ± 3.67

100.09 ± 14.43

111.13 ± 10.4

122.76 ± 15.75

77.34 ± 10.83

100%

2%

98.89 ± 18.96

5.73 ± 0.7

115.5 ± 41.59

46.56 ± 14.06

NA

144.43 ± 72.9

22

Schiavon (2020)

Brazil

RYGB

50

36

43 ± 9.1

72%

37.4 ± 3.43

102 ± 13.89

112.2 ± 9.2

123 ± 11.6

77.6 ± 7

100%

8%

98.4 ± 9.39

5.7 ± 0.63

121.5 ± 32.49

46.4 ± 14.42

NA

152.5 ± 79.21

Control

50

36

44.9 ± 9.2

56%

36.4 ± 3.43

100.1 ± 13.72

111.1 ± 9.2

122.8 ± 12.9

78 ± 9.3

100%

4%

98.6 ± 8.91

5.73 ± 0.62

120.8 ± 32.49

48.3 ± 14.42

NA

143.9 ± 72.89

23

O’Brien (2006)

Australia

“laparoscopic adjustable

gastric band”

39

24

41.8 ± 6.4

76%

33.7 ± 1.8

96.1 ± 11.2

103.3 ± 10

131.4 ± 14

83.2 ± 11.7

23%

NA

95.4 ± 34.2

NA

135.1 ± 52.1

50.2 ± 15.8

208.8 ± 62.7

128.3 ± 75.2

“very-lowcalorie diets,

pharmacotherapy,

and lifestyle change”

40

24

40.7 ± 7

77%

33.5 ± 1.4

93.6 ± 11.9

99.4 ± 9.4

130.3 ± 13.5

81 ± 9.1

17%

NA

90.1 ± 10.8

NA

135.1 ± 65.6

54.1 ± 25.9

215.7 ± 62.8

123.9 ± 79.6

24

O’Brien (2010)

Australia

“Laparoscopic

Adjustable Gastric”

25

24

16.5 ± 1.4

64%

42.3 ± 6.1

120.7 ± 25.3

120.8 ± 14.2

122 ± 13.9

72.4 ± 7.5

NA

NA

89 ± 20

NA

NA

46 ± 12

173 ± 27

124 ± 44

optimal lifestyle program

25

24

16.6 ± 1.2

72%

40.4 ± 3.1

115.4 ± 14

118.1 ± 10.6

132.8 ± 15.9

76.5 ± 10.5

NA

NA

82 ± 7.2

NA

NA

46 ± 8

178 ± 27

141 ± 141

25

Ospanov (2021)

Australia

“unstapled laparoscopic one anastomosis gastric bypass

with an obstructive stapleless pouch and anastomosis”

20

12

38.6 ± 6.89

90%

39.88 ± 5.8

108.95 ± 15.69

NA

135.8 ± 6.93

92.25 ± 3.97

NA

35%

117.18 ± 35.82

5.71 ± 5.36

NA

NA

209.97 ± 20.10

178.02 ± 42.5

“stapled laparoscopic mini-gastric

bypass-one anastomosis gastric bypass”

20

12

48.7 ± 8.54

75%

45.91 ± 5.5

128.95 ± 23.71

NA

142.4 ± 25.11

93.9 ± 4.15

NA

35%

106.02 ± 13.86

5.84 ± 0.61

NA

NA

200.31 ± 33.25

160.31 ± 63.7

“nonsurgical weight loss therapy

via a hypocaloric diet with energy restriction”

20

12

47.25 ± 9.85

65%

36.51 ± 8.1

101.13 ± 26.09

NA

138.9 ± 14.03

92.95 ± 3.24

NA

30%

108.9 ± 17.82

5.81 ± 0.7

NA

NA

213.07 ± 27.45

163.85 ± 43.3

26

Parikh (2014)

USA

bypass, sleeve or band

29

6

46.8 ± 8.1

79%

32.8 ± 1.7

81.96 ± 7.71

106.3 ± 10.1

126.4 ± 16.6

77 ± 13.3

NA

NA

149.6 ± 45.5

7.7 ± 1.4

101.8 ± 88.2

47.2 ± 15.5

193.4 ± 61.7

196.9 ± 188.2

intensive medical weight management

28

6

53.9 ± 8.4

78%

32.4 ± 1.8

83.68 ± 10.79

106.7 ± 7.7

129.1 ± 19

75.3 ± 8.1

NA

NA

143.6 ± 46.9

7.9 ± 1.3

116.1 ± 55.9

46.4 ± 13.2

193.9 ± 66.6

156.5 ± 69.1

27

Ruban (2021)

UK

“Duodenal-Jejunal Bypass Liner and

intensive medical care”

85

24

51.6 ± 7.9

45%

36.8 ± 5

107.9 ± 17.1

118.7 ± 12.3

130.3 ± 11.6

82 ± 9.7

58%

NA

NA

8.9 ± 0.9

95.5 ± 32.8

44.3 ± 9.6

175.6 ± 37.05

178.9 ± 96.5

intensive medical care

85

24

51.9 ± 8.5

45%

35.8 ± 4.2

104.2 ± 14.9

117.8 ± 16

133.3 ± 15

83.5 ± 10.6

62%

NA

NA

8.7 ± 0.9

93.9 ± 35.1

44.3 ± 11.5

170.6 ± 38.6

163.9 ± 72.6

28

Philip R. Schauer (2014)

USA

MEDICAL THERAPY

40

36

50.3 ± 7.51

67%

36.4 ± 2.99

113.3 ± 9.33

113.3 ± 9.33

135.3 ± 17.35

82.08 ± 11.15

65%

100%

157 ± 64.8

9 ± 1.4

100.9 ± 36.1

48.8 ± 12.95

NA

162 ± 107.3

RYGB

48

36

48 ± 8.45

58%

37.1 ± 3.39

116.6 ± 9.25

116.6 ± 9.25

135 ± 19.05

81.85 ± 10.18

73%

100%

193 ± 72.5

9.3 ± 1.4

92.4 ± 29.03

45.4 ± 13.01

NA

179 ± 102.3

SG

49

36

47.8 ± 8.08

77%

36.1 ± 3.91

113.6 ± 10.21

113.6 ± 10.21

135.8 ± 18.82

82.18 ± 11.59

61%

59%

164 ± 71

9.5 ± 1.7

105.8 ± 39.5

44.5 ± 12.01

NA

160 ± 70.2

29

Philip R. Schauer (2012)

USA

MEDICAL THERAPY

50

12

49.7 ± 7.4

62%

36.8 ± 3

106.5 ± 14.7

114.5 ± 9.4

135.5 ± 17

82.6 ± 11

52%

82%

155 ± 65.6

8.9 ± 1.4

101 ± 37.3

48.4 ± 13.1

NA

166 ± 103

RYGB

50

12

48.3 ± 8.4

58%

37 ± 3.3

106.7 ± 14.8

116.4 ± 9.2

134.6 ± 18.7

81.8 ± 10.2

70%

100%

193 ± 68.7

9.3 ± 1.4

91.8 ± 28.8

46.2 ± 13.4

NA

167 ± 100

SG

50

12

47.9 ± 8

44%

36.2 ± 3.9

100.8 ± 16.4

114 ± 10.4

135.8 ± 18.8

82.2 ± 11.6

60%

98%

164 ± 70.2

9.5 ± 1.7

105.8 ± 39.5

44.5 ± 12

NA

160 ± 69.4

  1. List of Abbreviations and Their Full Forms
  2. SG + TB Plus SMT: Sleeve Gastrectomy + Transit Bipartition Plus Standard Medical Therapy
  3. SMT: Standard Medical Therapy
  4. RYGB + LLLI: Roux-en-Y Gastric Bypass + Low-Level Lifestyle Intervention
  5. LAGB + LLLI: Laparoscopic Adjustable Gastric Banding + Low-Level Lifestyle Intervention
  6. ILWLI: Intensive Lifestyle and Weight Loss Intervention
  7. ESG + LSM: Endoscopic Sleeve Gastroplasty + Lifestyle Modifications
  8. LSM: Lifestyle Modifications
  9. RYGB: Roux-en-Y Gastric Bypass
  10. DJBL: Duodenal-Jejunal Bypass Liner
  11. BPD: Bilio-Pancreatic Diversion
  12. LAGB + MDC: Laparoscopic Adjustable Gastric Banding + Multidisciplinary Diabetes Care
  13. MDC: Multidisciplinary Diabetes Care
  14. ILI: Intensive Lifestyle Intervention
  15. MEDICAL THERAPY: Medical Therapy
  16. COT: Conventional Obesity Therapy
  17. WhyWAIT: Why Wait? Trial
  18. SG: Sleeve Gastrectomy