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Table 5 Sensitivity analysis with CAR as a mediating variable

From: Effect of limb ischemic preconditioning on the indirect index of insulin resistance in maintenance hemodialysis patients

 

model 1

model 2

model 3

ΔTyG

 total effect

(-0.63, -0.23)

(-0.6, -0.19)

(-0.48, -0.01)

 direct effect

(-0.52, -0.1)

(-0.5, -0.07)

(-0.43, -0.03)

 intermediary effect

(-0.26, -0.02)

(-0.25, -0.01)

(-0.22, 0.04)

ΔTyG-BMI

 total effect

(-21.36, -8.37)

(-20.18, -7.32)

(-18.04, -5.85)

 direct effect

(-17.03, -3.67)

(-16.47, -3.32)

(-15.83, -2.78)

 intermediary effect

(-9.03, -1.08)

(-8.11, -0.89)

(-8.00, 0.32)

  1. Model1: unadjusted for covariates
  2. Model2: adjusted for age, sex, BMI, glucose-lowering drugs, insulin
  3. Model3: adjusted for age, sex, BMI, glucose-lowering medication, insulin, blood glucose, urea nitrogen, creatinine, uric acid, albumin, HDL-C, Triglyceride
  4. The mediating effect is considered significant if the 95% confidence interval (BootLLCI - BootULCI) does not include zero