Fig. 4

Cumulative event rates for clinical outcomes at different NOAC doses. a-d: clinical outcome events occurring at 24 months of follow-up, e-h: clinical outcome events occurring at 60 months of follow-up. Different colors represent cumulative event rates for different NOAC doses. Clinical outcome events included: All-cause death, IS/SE, Bleeding and Composite endpoint. Statistical analysis was performed using log-rank, Statistically different at P < 0.05; IS/SE: Ischemic stroke/systemic embolism