Table 1 Comparison of baseline information of the patients according to the HGI
level | Overall | Q1 | Q2 | Q3 | Q4 | P-value | |
|---|---|---|---|---|---|---|---|
Number | 8055 | 2017 | 2011 | 2013 | 2014 | ||
Age (%) | > 65 | 4676 (58.05) | 1224 (60.68) | 1373 (68.27) | 1265 (62.84) | 814 (40.42) | < 0.0001 |
≤ 65 | 3379 (41.95) | 793 (39.32) | 638 (31.73) | 748 (37.16) | 1200 (59.58) | ||
Gender (%) | F | 3312 (41.12) | 851 (42.19) | 854 (42.47) | 774 (38.45) | 833 (41.36) | 0.0378 |
M | 4743 (58.88) | 1166 (57.81) | 1157 (57.53) | 1239 (61.55) | 1181 (58.64) | ||
Race (%) | Black | 1309 (16.25) | 297 (14.72) | 316 (15.71) | 290 (14.41) | 406 (20.16) | < 0.0001 |
Others | 1732 (21.50) | 390 (19.34) | 412 (20.49) | 463 (23.00) | 467 (23.19) | ||
White | 5014 (62.25) | 1330 (65.94) | 1283 (63.80) | 1260 (62.59) | 1141 (56.65) | ||
Marital status (%) | Divorced | 621 (7.71) | 141 (6.99) | 146 (7.26) | 155 (7.70) | 179 (8.89) | < 0.0001 |
Married | 3858 (47.90) | 927 (45.96) | 1021 (50.77) | 1029 (51.12) | 881 (43.74) | ||
Others | 377 (4.68) | 87 (4.31) | 91 (4.53) | 94 (4.67) | 105 (5.21) | ||
Single | 2198 (27.29) | 582 (28.85) | 464 (23.07) | 472 (23.45) | 680 (33.76) | ||
Widowed | 1001 (12.43) | 280 (13.88) | 289 (14.37) | 263 (13.07) | 169 (8.39) | ||
INR (median [IQR]) | 1.200 [1.100, 1.400] | 1.200 [1.100, 1.500] | 1.200 [1.100, 1.400] | 1.200 [1.100, 1.400] | 1.200 [1.100, 1.300] | < 0.0001 | |
PT (median [IQR]) | 13.200 [11.900, 15.500] | 13.400 [12.000, 16.200] | 13.300 [12.100, 15.800] | 13.200 [11.900, 15.300] | 12.900 [11.650, 14.800] | < 0.0001 | |
PTT (median [IQR]) | 31.000 [27.400, 39.900] | 31.800 [27.900, 41.600] | 31.200 [27.600, 40.700] | 30.800 [27.075, 38.425] | 30.300 [26.800, 38.300] | < 0.0001 | |
Heart rate (median [IQR]) | 83.250 [74.381, 93.375] | 83.014 [73.383, 93.885] | 82.370 [73.832, 92.464] | 82.509 [74.571, 91.945] | 85.094 [75.850, 95.236] | < 0.0001 | |
SBP (median [IQR]) | 117.500 [108.200, 130.401] | 117.286 [107.355, 130.208] | 117.027 [107.920, 129.687] | 117.465 [108.610, 130.027] | 118.319 [109.542, 132.028] | 0.001 | |
DBP (median [IQR]) | 60.389 [54.219, 68.560] | 60.364 [54.175, 68.243] | 59.481 [53.553, 67.370] | 59.213 [53.423, 67.343] | 62.929 [56.243, 70.625] | < 0.0001 | |
MBP (median [IQR]) | 76.320 [70.577, 84.160] | 76.350 [70.319, 84.520] | 75.667 [70.000, 83.220] | 75.310 [70.152, 83.258] | 77.965 [71.896, 86.000] | < 0.0001 | |
SPO2 (median [IQR]) | 97.259 [95.913, 98.500] | 97.200 [95.800, 98.439] | 97.261 [95.880, 98.437] | 97.180 [95.941, 98.529] | 97.387 [96.039, 98.577] | 0.0512 | |
Hemoglobin (median [IQR]) | 10.600 [9.100, 12.300] | 10.600 [8.900, 12.200] | 10.600 [9.100, 12.100] | 10.500 [9.100, 12.100] | 10.800 [9.100, 12.600] | 0.0058 | |
Hematocrit (median [IQR]) | 32.100 [27.900, 37.000] | 31.900 [27.500, 37.000] | 32.000 [27.900, 36.800] | 32.050 [27.925, 36.600] | 32.700 [28.100, 37.675] | 0.0014 | |
MCV (median [IQR]) | 90.000 [86.000, 94.000] | 91.000 [87.000, 96.000] | 90.000 [86.000, 94.000] | 90.000 [86.000, 94.000] | 89.000 [85.000, 93.000] | < 0.0001 | |
MCH (median [IQR]) | 29.700 [28.000, 31.100] | 30.100 [28.500, 31.500] | 29.700 [28.000, 31.100] | 29.500 [28.000, 30.900] | 29.300 [27.700, 30.700] | < 0.0001 | |
Temperature (median [IQR]) | 36.803 [36.590, 37.057] | 36.803 [36.591, 37.057] | 36.797 [36.586, 37.042] | 36.790 [36.584, 37.039] | 36.826 [36.602, 37.082] | 0.0175 | |
RBC (median [IQR]) | 3.620 [3.110, 4.200] | 3.540 [3.020, 4.130] | 3.590 [3.100, 4.170] | 3.620 [3.130, 4.162] | 3.720 [3.170, 4.320] | < 0.0001 | |
WBC (median [IQR]) | 8.600 [6.500, 11.700] | 8.300 [6.100, 11.400] | 8.600 [6.500, 11.675] | 8.900 [6.800, 11.800] | 8.800 [6.600, 11.800] | < 0.0001 | |
eGFR (median [IQR]) | 29.729 [0.000, 58.091] | 23.641 [0.000, 58.050] | 28.422 [0.000, 56.846] | 34.995 [0.000, 58.771] | 31.048 [0.000, 59.050] | 0.0142 | |
Lymphocytes (median [IQR]) | 19.300 [12.100, 27.200] | 18.900 [11.700, 26.900] | 19.600 [12.700, 27.500] | 19.500 [12.600, 27.000] | 19.000 [11.500, 27.300] | 0.1513 | |
Neutrophils (median [IQR]) | 71.400 [62.500, 80.000] | 71.200 [62.000, 79.900] | 71.000 [62.600, 79.800] | 71.000 [62.800, 79.600] | 72.400 [62.600, 80.800] | 0.1591 | |
APSIII (median [IQR]) | 42.000 [31.000, 55.000] | 42.000 [31.000, 56.000] | 41.000 [31.000, 55.000] | 41.000 [31.000, 54.000] | 42.000 [32.000, 54.000] | 0.3572 | |
SAPSII (median [IQR]) | 35.000 [28.000, 44.000] | 36.000 [29.000, 45.000] | 36.000 [30.000, 45.000] | 35.000 [28.000, 44.000] | 33.000 [25.000, 42.000] | < 0.0001 | |
SIRS (median [IQR]) | 3.000 [2.000, 3.000] | 3.000 [2.000, 3.000] | 3.000 [2.000, 3.000] | 3.000 [2.000, 3.000] | 3.000 [2.000, 3.000] | 0.1052 | |
SOFA (median [IQR]) | 4.000 [2.000, 6.000] | 5.000 [2.000, 7.000] | 4.000 [2.000, 6.000] | 4.000 [2.000, 6.000] | 4.000 [2.000, 6.000] | < 0.0001 | |
Insulin (%) | No | 169 (2.10) | 109 (5.40) | 49 (2.44) | 8 (0.40) | 3 (0.15) | < 0.0001 |
Yes | 7886 (97.90) | 1908 (94.60) | 1962 (97.56) | 2005 (99.60) | 2011 (99.85) | ||
Myocardial infarction | No | 6327 (78.55) | 1645 (81.56) | 1583 (78.22) | 1540 (76.50) | 1559 (77.41) | 0.0006 |
Yes | 1728 (21.45) | 372 (18.44) | 428 (21.28) | 473 (23.50) | 455 (22.59) | ||
CKD (%) | No | 6177 (76.69) | 1532 (75.95) | 1596 (79.36) | 1566 (77.79) | 1483 (73.63) | 0.0001 |
Yes | 1878 (23.31) | 485 (24.05) | 415 (20.64) | 447 (22.21) | 531 (26.37) | ||
CHF (%) | No | 5467 (67.87) | 1390 (68.91) | 1345 (66.88) | 1301 (64.63) | 1431 (71.05) | 0.0001 |
Yes | 2588 (32.13) | 627 (31.09) | 666 (33.12) | 712 (35.37) | 583 (28.95) | ||
COPD (%) | No | 7139 (88.63) | 1740 (86.27) | 1775 (88.26) | 1796 (89.22) | 1828 (90.76) | 0.0001 |
Yes | 916 (11.37) | 277 (13.73) | 236 (11.74) | 217 (10.78) | 186 (9.24) | ||
Severe liver disease (%) | No | 7782 (96.61) | 1899 (94.15) | 1964 (97.66) | 1956 (97.17) | 1963 (97.47) | < 0.0001 |
Yes | 273 (3.39) | 118 (5.85) | 47 (2.34) | 57 (2.83) | 51 (2.53) | ||
Hypertension (%) | No | 2300 (28.55) | 574 (28.46) | 527 (26.21) | 552 (27.42) | 647 (32.13) | 0.0002 |
Yes | 5755 (71.45) | 1443 (71.54) | 1484 (73.79) | 1461 (72.58) | 1367 (67.87) |