Skip to main content
Fig. 6 | BMC Cardiovascular Disorders

Fig. 6

From: Alkbh5 promotes Ythdf1 expression through demethylation thereby facilitating Fth1 translation to inhibit ferroptosis of myocardial infarction

Fig. 6

Alkbh5 improved myocardial injury in the MIRI rat model through promoting Fth1 translation by increasing Ythdf1 expression. (A) The myocardial injury of rats in different groups was assessed by HE and Masson’s trichrome staining. (B) The quantitative results of myocardial fibrosis evaluated by Masson’s trichrome staining. (C-E) Myocardial injury was assessed by the levels of myocardial injury markers LDH activity, CK-MB and cTnI. (F and G) The expression of Ythdf1 and Fth1 was measured by qPCR. (H) The protein level of Fth1 was measured by western blot. (I-J) Ferroptosis of cardiac tissues of rats were evaluated by measuring SOD, MDA, Fe2+ and ROS levels. (M and N) qPCR was performed to measure GPX4 and ACSL4 mRNA expression

Back to article page

BMC Cardiovascular Disorders

ISSN: 1471-2261

Contact us