VEGF-A cis-located SNPs on human chromosome 6 associated with VEGF-A plasma levels and survival in a coronary disease cohort

Table 5 Multivariate regression model for all-cause mortality in the CDCS cohort using imputed genotypes for rs6921438 and rs7767396 (n = 509, 166 (32.6%) events)

Predictor	Coeff.	SE	Wald	P-value	HR	95% CI for HR
Predictor	Coeff.	SE	Wald	P-value	HR	Lower	Upper
Gender	0.015	0.190	0.007	0.935	1.02	0.700	1.47
Ethnicity			0.923	0.820
European v Māori/Pasifika	-0.797	1.08	0.602	0.438	0.451	0.060	3.38
European v Asian	-7.23	226.3	0.001	0.975	0.001	1.85 × 10^− 196	2.85 × 10¹⁸⁹
European v MELAA	-1.39	1.484	0.888	0.346	0.247	0.013	4.53
Physical Activity (scale 1–4)^$$	-0.309	0.069	20.1	7.16 × 10^− 6	0.734	0.642	0.840
Previous MI	0.590	0.167	12.5	4.06 × 10^− 4	1.803	1.301	2.501
Age	0.064	0.012	30.6	3.08 × 10^− 8	1.07	1.042	1.09
Body mass index	-0.053	0.021	6.09	0.014	0.948	0.909	0.989
Urate	1.52	0.840	3.27	0.071	4.57	0.881	23.7
Creatinine	0.005	0.001	11.9	0.001	1.005	1.002	1.008
Beta blocker	-0.128	0.230	0.310	0.578	0.880	0.561	1.38
Statin	-0.195	0.199	0.962	0.327	0.823	0.557	1.22
Log10 NTproBNP^$	0.860	0.253	11.5	0.001	2.36	1.44	3.88
Log10 VEGF-A^$	0.974	0.295	10.9	0.001	2.65	1.49	4.73
rs6921438 genotype			7.34	0.026
GG v GA	-0.199	0.477	0.175	0.676	0.819	0.322	2.09
GG v AA	-1.47	0.649	5.13	0.024	0.230	0.064	0.820
rs7767396 genotype			10.1	0.006
AA v AG	0.074	0.488	0.023	0.879	1.08	0.414	2.804
AA v GG	1.56	0.646	5.82	0.016	4.76	1.34	16.9
Time to sampling	0.003	0.008	0.202	0.653	1.003	0.988	1.02

$Hazard Ratio represents the change in risk for every 10-fold increase in NTproBNP or VEGF-A level
$$Score of 1 = sedentary, 2 = < 30 min activity on > 2 days/week, 3 = ≥ 30 min on 2 days/week, 4 = ≥ 30 min on ≥ 3 days/week
Significant variables and their p-values are in bold
Abbreviations: CI = confidence interval, Coeff = Coefficient, HR = Hazard Ratio, MI = Myocardial Infarction, NTproBNP = amino-terminal pro-B type natriuretic peptide, SE = standard error, VEGF-A = Vascular endothelial growth factor A

ISSN: 1471-2261