VEGF-A cis-located SNPs on human chromosome 6 associated with VEGF-A plasma levels and survival in a coronary disease cohort

Table 6 Multivariate regression model for heart failure readmissions in the CDCS cohort including manual genotypes for rs6921438 and rs7767396 (n = 462, 109 (23.6%) events)

Predictor	Coeff.	SE	Wald	P-value	HR	95% CI for HR
Predictor	Coeff.	SE	Wald	P-value	HR	Lower	Upper
Gender	0.277	0.241	1.32	0.250	1.32	0.823	2.114
Ethnicity			6.41	0.093
European v Māori & Pasifika	1.09	0.683	2.58	0.108	2.99	0.785	11.434
European v Asian	2.18	1.09	3.97	0.046	8.91	1.03	76.645
European v MELAA	-4.71	204.8	0.001	0.982	0.009	3.9 × 10^− 177	1.9 × 10¹⁷²
Physical Activity (scale 1–4)^$$	-0.397	0.086	21.3	3.95 × 10^− 6	0.672	0.568	0.796
Previous MI	0.673	0.203	10.9	0.001	1.96	1.31	2.918
Age	0.063	0.014	19.3	1.07 × 10^− 5	1.065	1.03	1.095
Body mass index	-0.012	0.030	0.153	0.695	0.988	0.931	1.049
Urate	2.97	1.09	7.51	0.006	19.6	2.33	165.220
Creatinine	0.002	0.002	1.23	0.267	1.002	0.998	1.006
Beta blocker	-0.589	0.279	4.46	0.035	0.555	0.322	0.958
Statin	0.101	0.263	0.147	0.702	1.106	0.661	1.851
Log10 NTproBNP^$	1.75	0.358	23.7	1.1 × 10^− 6	5.72	2.83	11.547
Log10 VEGF-A^$	0.952	0.401	5.63	0.018	2.59	1.18	5.680
rs6921438 genotype			7.29	0.026
GG v GA	0.607	0.680	0.797	0.372	1.83	0.484	6.959
GG v AA	1.88	0.790	5.66	0.017	6.55	1.39	30.792
rs7767396 genotype			7.72	0.021
AA v AG	-0.455	0.655	0.482	0.488	0.635	0.176	2.292
AA v GG	-1.902	0.800	5.65	0.017	0.149	0.031	0.716
Time to sampling	0.021	0.010	4.59	0.032	1.02	1.002	1.041
LVEF at baseline	0.001	0.008	0.006	0.937	1.001	0.985	1.016

$Hazard Ratio represents the change in risk for every 10-fold increase in NTproBNP or VEGF-A level
$$Score of 1 = sedentary, 2 = < 30 min activity on > 2 days/week, 3 = ≥ 30 min on 2 days/week, 4 = ≥ 30 min on ≥ 3 days/week
Significant variables and their p-values are in bold
Abbreviations: CI = confidence interval, Coeff = Coefficient, LVEF = left ventricular ejection fraction, MI = Myocardial Infarction, NTproBNP = amino-terminal pro-B type natriuretic peptide, SE = standard error, VEGF-A = Vascular endothelial growth factor A

ISSN: 1471-2261