Table 1 Patient demographics and baseline characteristics

Age

74.2 ± 8.3

76.5 ± 8.7

0.026

Gender

365 (42.7%)

61 (46.2%)

0.447

Height

162.9 ± 8

162.8 ± 8.6

0.875

Weight

62.4 ± 11.1

60.6 ± 11.2

0.081

BMI

23.4 ± 3.4

22.8 ± 3.9

0.103

BSA

1.5 ± 1.7

1.6 ± 1.7

0.134

AVA

0.86 ± 0.52

0.80 ± 0.45

0.213

PASP

139 (16.1%)

55 (41.5%)

< 0.001

Hb

125.1 ± 19.2

119.5 ± 20.7

0.004

TnT

0.05 ± 0.02

0.07 ± 0.02

0.424

BAV

419 (49.0%)

47 (35.6%)

0.004

LVEF

59.8 ± 10.6

51.5 ± 13.8

< 0.001

LAD

42.9 ± 6.4

47.4 ± 6.9

< 0.001

LVEDD

49.9 ± 7.5

54.3 ± 9.4

< 0.001

BAV Type

212 (24.8%)

20 (15.2%)

0.015

Creatinine

102.2 ± 98.7

127.6 ± 12.4

0.029

Creatinine clearance

67.2 ± 18.5

61.1 ± 21.5

0.002

PCI

75 (8.8%)

20 (15.2%)

0.012

Diabetes

178 (20.8%)

21 (18.9%)

0.117

NYHA

737 (86.1%)

123 (93%)

< 0.001

AVB

66 (7.7%)

11 (8.3%)

0.229

LBBB

16 (1.9%)

1 (0.8%)

0.810

RBBB

43 (5%)

6 (4.5%)

> 0.999

CAD

603 (70.5%)

98 (74.2%)

0.381

MI

11 (1.3%)

6 (4.5%)

0.018

CABG

8 (0.9%)

4 (3.0%)

0.064

AF

146 (17.1%)

43 (32.6%)

< 0.001

PMM

16 (1.9%)

11 (8.3%)

< 0.001

COPD

44 (5.1%)

11 (8.3%)

0.137

Cancer

38 (4.4%)

10 (7.6%)

0.120

Stroke

45 (5.3%)

10 (7.6%)

0.281

HF

412 (48.2%)

101 (76.5%)

< 0.001

Aspirin

386 (45.1%)

67 (50.8%)

0.229

Smoker

77 (9.0%)

14 (10.6%)

0.554

Syncope

48 (5.6%)

13 (9.8%)

0.060

Warfarin

27 (3.2%)

10 (7.6%)

0.023

Hypertension

517 (60.5%)

69 (52.3%)

0.074

Carotiddisease

97 (11.3%)

19 (14.4%)

0.311

Periphdisease

45 (5.3%)

23 (17.4%)

< 0.001

Hyperuricaemia

8 (0.9%)

6 (4.5%)

0.006

Surgery history

67 (7.8%)

8 (6.1%)

0.474

Aortic orifice area

474.3 ± 95.1

480.8 ± 109.9

0.551

Pulmonary infection

21 (2.5%)

0 (0.0%)

0.098

Maximum aortic valve velocity

4.4 ± 0.9

4.2 ± 1

0.220

Mean pressure gradient

81.5 ± 31.6

76.4 ± 31.7

0.087

Moderate to severe AR

257 (29.9%)

50 (37.8%)

0.021

Mitral valve calcification

94 (11.0%)

25 (18.9%)

0.009

Mitral valve leaflet adhesion

16 (1.9%)

7 (5.3%)

0.025

Mitral valve leaflet thickening

38 (4.4%)

33 (25.0%)

< 0.001

Aortic annulus diameter

22.5 ± 2.3

22.7 ± 2.7

0.306

Aortic annulus circumference

80.1 ± 7.8

80.2 ± 10.3

0.907

Effective aortic orifice area

84.9 ± 64.8

85.4 ± 67.1

0.954

Calcification of the aortic valve

706 (82.6%)

109 (82.6%)

> 0.999

Right coronary artery hight

15.2 ± 3.5

15.5 ± 3.8

0.447

Left coronary artery hight

14.3 ± 5.3

14 ± 3.3

0.556

Autoimmune diseases

13 (1.5%)

3 (2.3%)

0.462

P2Y12 receptor antagonists

428 (50.1%)

73 (55.3%)

0.262

XaII factor antagonist

190 (22.2%)

34 (25.8%)

0.367