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Table 3 Therapeutic profile of people living with hypertension

From: Prevalence and determinants of apparent treatment-resistant hypertension among patients in South African primary care: a single-centre observational study

 

Total

N = 400

No aTRH

N = 325

aTRH

N = 75

p-value

Total prescription medication count

median (IQR)

7(4)

7(3)

9(3)

< 0.001

Total anti-hypertensives

median (IQR)

3(2)

3(1)

4(1)

< 0.001

Number of anti-hypertensive agents n (%)

    

1 agent

44(11.0)

44(11.0)

0(0)

< 0.001

2 agents

100(25.0)

100(25.0)

0(0)

< 0.001

3 agents

149(37.3)

136(41.8)

13(17.3)

0.000

4 agents

58(14.5)

23(7.1)

35(46.7)

0.000

5 agents

32(8.0)

13(4.0)

19(25.3)

0.000

6 agents

15(3.8)

9(2.7)

6(8.0)

0.032

7 agents

2(0.5)

0(0)

2(2.7)

0.003

Drug class use n (%)

    

RAAS Blockers

294(73.5)

226(69.5)

68(90.7)

< 0.001

 ACE-I

267(66.8)

205(63.1)

62(82.7)

0.001

 ARB

27(6.8)

21(6.5)

6(8.0)

0.395

Dihydropyridine Calcium Channel Blocker

272(68.0)

204(62.8)

68(90.7)

< 0.001

Beta-blocker

118(29.5)

74(22.8)

44(58.6)

< 0.001

Alpha blocker

57(14.3)

32(9.8)

25(33.3)

< 0.001

Vasodilator

54(13.5)

33(10.2)

21(28.0)

< 0.001

Diuretic

    

 Thiazide

225(56.3)

187(57.5)

38(50.6)

0.280

 Loop

124(31.0)

87(26.8)

37(49.3)

< 0.001

Mineralocorticoid Receptor Antagonist

43(10.8)

19(5.8)

24(32.0)

< 0.001

Other drugs

    

Lipid-lowering therapy

327(81.8)

260(80.0)

67(89.3)

0.059

Tricyclic anti-depressants

97(24.3)

77(23.7)

20(26.7)

0.588

Non-steroidal anti-inflammatory drugs

53(13.3)

44(13.5)

9(12.0)

0.723

Oral corticosteroids

11(2.75)

11(3.4)

0(0)

0.230