Table 2 Comparison of demographic, clinical characteristics, and outcomes across KILLIP classes in the dataset
Variable | Killip classification | P value | |||
|---|---|---|---|---|---|
Case number | 1 (n = 1005) | 2 (n = 468) | 3 (n = 72) | 4 (n = 29) |  |
Sex, Male, n (%) | 816(81.2) | 356(76.1) | 50(69.4) | 22(75.9) | 0.023 |
Age(year) | 60.5 ± 12.3 | 68.1 ± 11.5 | 70.4 ± 10.4 | 65.4 ± 11.2 | < 0.001 |
BMI, kg/m2 | 25.7 ± 3.6 | 25.5 ± 3.6 | 25.1 ± 3.5 | 24.5 ± 2.9 | 0.212 |
History of hypertension, n (%) | 575(57.2) | 309(66) | 51(70.8) | 15(51.7) | 0.002 |
History of hyperlipidemia, n (%) | 183(18.2) | 63(13.5) | 9(12.5) | 2(6.9) | 0.044 |
History of diabetes, n (%) | 339(33.7) | 219(46.8) | 36(50) | 14(48.3) | < 0.001 |
History of AF, n (%) | 28(2.8) | 23(4.9) | 36(50) | 14(48.3) | < 0.001 |
Old myocardial infarction, n (%) | 101(10) | 92(19.7) | 3(4.2) | 5(17.2) | < 0.001 |
History of stent implantation, n (%) | 105(10.4) | 90(19.2) | 13(18.1) | 4(13.8) | < 0.001 |
History of CABG, n (%) | 9(0.9) | 11(2.4) | 1(1.4) | 1(3.4) | 0.121 |
History of smoking, n (%) | 627(62.6) | 256(54.7) | 36(50) | 15(51.7) | 0.008 |
No quitting smoking, n (%) | 511(50.8) | 189(40.4) | 23(31.9) | 11(37.9) | 0.034 |
History of CVD, n (%) | 101(2.1) | 1(5.9) | 1(8.3) | 2(22.2) | 0.123 |
History of PU, n (%) | 29(2.9) | 11(2.6) | 4(5.6) | 0(0) | 0.164 |
GRACE risk score | 138.0 ± 29.0 | 170.1 ± 30.1 | 203.8 ± 35.8 | 231.5 ± 33.0 | < 0.001 |
TIMI risk score | 3.4 ± 1.7 | 5.3 ± 2.1 | 5.6 ± 2.2 | 6.1 ± 2.7 | < 0.001 |
Blood glucose, mmol/L | 6.8 ± 4.3 | 10.0 ± 47.4 | 8.6 ± 4.8 | 9.0 ± 4.3 | 0.177 |
HbA1c, % | 6.5 ± 1.5 | 6.9 ± 1.7 | 7.1 ± 1.6 | 6.9 ± 1.8 | < 0.001 |
Creatinine, umol/L | 74.4 ± 20.3 | 88.8 ± 56.0 | 121.0 ± 54.9 | 114.9 ± 50.6 | < 0.001 |
CCR, mL/min | 90.1 ± 45.1 | 74.1 ± 72.7 | 51.7 ± 24.4 | 53.6 ± 26.5 | < 0.001 |
TC, mmol/L | 4.2 ± 1.0 | 4.1 ± 1.0 | 3.9 ± 1.4 | 3.9 ± 1.2 | 0.023 |
LDL-C, mmol/L | 2.6 ± 0.8 | 2.7 ± 3.4 | 2.5 ± 1.1 | 2.2 ± 0.9 | 0.698 |
HDL-C, mmol/L | 1.0 ± 0.3 | 1.0 ± 0.3 | 1.1 ± 0.3 | 1.1 ± 0.4 | 0.647 |
TG, mmol/L | 1.9 ± 1.3 | 1.7 ± 1.0 | 1.5 ± 0.7 | 1.3 ± 0.6 | < 0.001 |
UA, mmol/L | 348.9 ± 94.1 | 363.0 ± 116.1 | 405.0 ± 158.7 | 416.8 ± 177.1 | < 0.001 |
ALT, IU/L | 43.8 ± 59.9 | 40.5 ± 35.2 | 70.8 ± 148.1 | 95.1 ± 123.0 | < 0.001 |
AST, IU/L | 95.1 ± 109.9 | 96.2 ± 122.8 | 119.4 ± 183.4 | 190.7 ± 338.1 | < 0.001 |
Peak troponin I, ng/mL | 15.5 ± 17.9 | 36.8 ± 331.1 | 15.8 ± 19.1 | 28.6 ± 19.4 | 0.211 |
NT-pro BNP, pg/mL | 998.0 ± 2257.5 | 3550.4 ± 5890.4 | 10567.0 ± 9999.6 | 9448.9 ± 10009.3 | < 0.001 |
hs-CRP, mg/L | 10.9 ± 14.2 | 16.2 ± 17.0 | 28.4 ± 18.6 | 25.2 ± 19.0 | < 0.001 |
IL-6, pg/mL | 32.2 ± 82.1 | 49.3 ± 126.6 | 79.1 ± 117.3 | 1874.4 ± 9257.9 | < 0.001 |
Leukocytes, n×103/µL | 9.5 ± 3.1 | 9.9 ± 3.3 | 11.0 ± 4.5 | 12.9 ± 4.4 | < 0.001 |
Neutrophils, n×103/µL | 7.3 ± 3.6 | 7.7 ± 3.3 | 8.7 ± 4.3 | 10.6 ± 4.2 | < 0.001 |
Lymphocytes, n×103/µL | 1.7 ± 0.8 | 1.6 ± 0.8 | 1.5 ± 0.9 | 1.5 ± 0.8 | 0.006 |
Monocytes, n×103/µL | 0.5 ± 0.2 | 0.6 ± 0.3 | 0.7 ± 0.4 | 0.7 ± 0.5 | < 0.001 |
Platelet, n×103/µL | 228.2 ± 63.2 | 226.7 ± 77.1 | 236.1 ± 103.1 | 247.6 ± 115.6 | 0.357 |
Hemoglobin, g/L | 138.1 ± 17.0 | 132.7 ± 19.1 | 98.8 ± 20.8 | 121.6 ± 19.8 | < 0.001 |
Left atrial diameter, mm | 37.5 ± 4.7 | 38.6 ± 5.8 | 40.1 ± 5.9 | 39.6 ± 7.1 | < 0.001 |
LVEDD, mm | 51.5 ± 5.1 | 52.6 ± 6.0 | 56.8 ± 7.4 | 54.3 ± 7.0 | < 0.001 |
LVEF, % | 57.2 ± 9.0 | 52.7 ± 11.0 | 42.3 ± 12.7 | 41.7 ± 9.8 | < 0.001 |
Length of hospitalization | 8.5 ± 3.8 | 10.3 ± 7.3 | 15.7 ± 11.4 | 17.4 ± 13.2 | < 0.001 |