| All patients (n = 20) | Sinus rhythm (n = 17) | Atrial fibrillation (n = 3) | P |
---|---|---|---|---|
Age, years | 67 (50–76) | 66 (48–74) | 79 (70–80) | 0.203 |
Male | 17 (85) | 14 (82) | 3 (100) | 0.430 |
Body surface area, m2 | 1.63 (1.49–1.80) | 1.58 (1.49–1.79) | 1.77 (1.67–1.86) | 0.266 |
NYHA functional class I/II/III | 10/9/1 | 9/7/1 | 1/2/0 | 0.666* |
Aetiology of HF | Â | Â | Â | Â |
Ischaemic cardiomyopathy | 6 (30) | 5 (29) | 1 (33) | 0.891 |
Dilated cardiomyopathy | 2 (10) | 2 (12) | 0 (0) | 0.531 |
Hypertrophic cardiomyopathy | 1 (5) | 1 (6) | 0 (0) | 0.666 |
Valvular heart disease | 3 (15) | 2 (12) | 1 (33) | 0.334 |
Hypertensive heart disease | 3 (15) | 2 (12) | 1 (33) | 0.334 |
Cardiac amyloidosis | 2 (10) | 2 (12) | 0 (0) | 0.531 |
Cardiac sarcoidosis | 1 (5) | 1 (6) | 0 (0) | 0.666 |
Anthracycline-induced cardiomyopathy | 1 (5) | 1 (6) | 0 (0) | 0.666 |
Post-myocarditis | 1 (5) | 1 (6) | 0 (0) | 0.666 |
Comorbidity | Â | Â | Â | Â |
Hypertension | 9 (45) | 7 (41) | 2 (67) | 0.413 |
Diabetes mellitus | 7 (35) | 6 (35) | 1 (33) | 0.947 |
Dyslipidaemia | 11 (55) | 9 (53) | 2 (67) | 0.659 |
Chronic obstructive pulmonary disease | 1 (5) | 0 (0) | 1 (33) | 0.014 |
Medical therapy | Â | Â | Â | Â |
Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker | 12 (60) | 10 (59) | 2 (67) | 0.798 |
Angiotensin receptor-neprilysin inhibitor | 1 (5) | 0 (0) | 1 (33) | 0.014 |
Beta-blocker | 11 (55) | 9 (53) | 2 (67) | 0.659 |
Mineralocorticoid receptor antagonist | 7 (35) | 6 (35) | 1 (33) | 0.947 |
Sodium-glucose cotransporter 2 inhibitor | 5 (25) | 4 (24) | 1 (33) | 0.717 |
Loop diuretic | 13 (65) | 10 (59) | 3 (100) | 0.168 |
Laboratory measurement | Â | Â | Â | Â |
Haemoglobin, g/dL | 13.0 (10.9–13.7) | 12.7 (10.7–13.2) | 14.4 (13.8–16.4) | 0.063 |
Sodium, mEq/L | 140 (137–141) | 140 (137–141) | 140 (139–141) | 0.871 |
Albumin, g/dL | 4.0 (3.8–4.2) | 4.0 (3.7–4.2) | 3.8 (3.8–4.0) | 0.915 |
Creatinine, mg/dL | 1.05 (0.87–1.29) | 0.99 (0.86–1.23) | 1.35 (1.32–1.46) | 0.026 |
BNP, pg/mL | 209.9 (46.6–396.1) | 176.4 (40.8–399.8) | 245.4 (226.9–320.1) | 0.560 |
NT-proBNP, pg/mL | 1572 (521–2355) | 966 (227–2258) | 1887 (1779–2444) | 0.248 |
High-sensitivity C-reactive protein, mg/dL | 0.08 (0.04–0.53) | 0.07 (0.03–0.58) | 0.48 (0.26–0.49) | 0.779 |
Electrocardiography | Â | Â | Â | Â |
Sinus rhythm | 17 (85) | 17 (100) | 0 (0) | < 0.001 |
Atrial fibrillation | 3 (15) | 0 (0) | 3 (100) | < 0.001 |
Heart rate, bpm | 71 (64–82) | 71 (64–81) | 70 (45–87) | 0.697 |
Echocardiography | Â | Â | Â | Â |
LAD, mm | 44.4 (42.1–46.9) | 44.0 (40.8–46.8) | 45.6 (44.7–58.1) | 0.289 |
LVEDD, mm | 55.3 (46.5–65.8) | 54.0 (45.4–65.8) | 61.5 (56.0–67.6) | 0.314 |
LVEF (Teichholz), % | 37.6 (25.3–61.0) | 44.7 (28.5–60.7) | 20.8 (16.5–30.5) | 0.101 |
LVEF (Simpson), % | 38.8 (26.3–62.2) | 44.7 (26.4–63.0) | 35.7 (22.9–36.8) | 0.185 |
E/e′ | 17.8 (11.0–21.6) | 16.1 (10.7–21.5) | 21.6 (18.5–23.9) | 0.289 |
Moderate or severe mitral regurgitation | 3 (15) | 1 (6) | 2 (67) | 0.006 |