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Table 1 Baseline characteristics of critical patients with ischemic heart disease according to SHRa tertiles

From: Stress hyperglycemia ratio linked to all-cause mortality in critically ill patients with ischemic heart disease

Variables

Overall (n = 2559)

T1 (n = 854)

T2 (n = 846)

T3 (n = 859)

P-value

Age, years

67.09 ± 12.22

66.84 ± 12.38

67.09 ± 12.37

67.33 ± 11.92

0.71

Male, n (%)

1654(64.63)

546(63.93)

585(69.15)

523(60.88)

< 0.01

BMI, kg/m2

29.65 ± 6.93

29.65 ± 7.06

29.73 ± 7.13

29.58 ± 6.61

0.90

SOFA score

3.00(2.00,5.00)

3.00(2.00,5.00)

3.00(1.25,5.00)

4.00(2.00,6.00)

< 0.0001

SAPS II

32.00(25.00,40.00)

31.00(25.00,39.00)

30.00(24.00,38.00)

35.00(27.00,44.00)

< 0.0001

APS III

37.00(28.00,48.00)

35.00(27.00,46.00)

34.00(27.00,44.00)

41.00(31.00,55.00)

< 0.0001

SIRS score

3.00(2.00,3.00)

2.00(1.00,3.00)

2.50(2.00,3.00)

3.00(2.00,4.00)

< 0.0001

Comorbidities, n (%)

    

 AMI

1281(50.06)

372(43.56)

448(52.96)

461(53.67)

< 0.0001

 DM

1279(49.98)

481(56.32)

345(40.78)

453(52.74)

< 0.0001

 Hypertension

1390(54.32)

461(53.98)

494(58.39)

435(50.64)

< 0.01

 AF

841(32.86)

274(32.08)

255(30.14)

312(36.32)

0.02

 COPD

439(17.16)

158(18.50)

122(14.42)

159(18.51)

0.04

 AKIb

455(17.78)

141(16.51)

133(15.72)

181(21.07)

< 0.01

 CKD

687(26.85)

262(30.68)

185(21.87)

240(27.94)

< 0.001

 PCI

588(22.98)

164(19.20)

231(27.30)

193(22.47)

< 0.001

Laboratory tests

     

 WBC, K/uL

10.80(8.10,13.90)

9.50(7.50,12.50)

10.60(8.00,13.40)

11.90(9.20,15.50)

< 0.0001

 Serum sodium, mEq/L

137.99 ± 3.94

138.57 ± 3.69

137.83 ± 3.53

137.56 ± 4.45

< 0.0001

 Serum potassium, mEq/L

4.24 ± 0.74

4.17 ± 0.72

4.20 ± 0.68

4.33 ± 0.81

< 0.0001

 Scr, mg/dL

1.00(0.80,1.50)

1.00(0.80,1.50)

1.00(0.80,1.30)

1.10(0.90,1.60)

< 0.0001

 Glucose, mg/dL

142.00(113.00,188.00)

106.00(94.00,125.00)

135.00(121.00,156.75)

203.00(169.00,258.00)

< 0.0001

 HbA1c, %

6.20(5.70,7.10)

6.50(5.90,7.60)

6.00(5.60,6.70)

6.10(5.60,6.90)

< 0.0001

 LDL, mg/dL

80.00(58.49,105.00)

80.00(59.00,104.00)

82.00(60.00,107.14)

79.50(57.00,103.00)

0.48

 HDL, mg/dL

43.00(35.00,54.00)

43.00(36.00,53.96)

43.91(35.00,53.01)

43.00(34.58,54.47)

0.98

 TG, mg/dL

125.00(81.00,188.00)

127.00(85.00,194.65)

121.00(78.00,178.88)

128.00(81.00,188.50)

0.17

 TC, mg/dL

154.00(124.00,183.00)

154.00(124.00,182.00)

154.78(125.00,185.00)

153.00(123.50,183.41)

0.93

 APTT, s

31.70(26.80,42.50)

31.50(26.90,40.07)

31.80(26.70,43.38)

32.00(26.90,44.40)

0.18

 PT, s

13.80(12.90,15.40)

13.75(12.83,15.30)

13.70(12.80,15.40)

13.90(13.00,15.40)

0.28

 INR

1.20(1.10,1.50)

1.20(1.10,1.40)

1.20(1.10,1.50)

1.20(1.10,1.50)

0.03

 lactate, mmol/L

1.70(1.10,2.66)

1.50(1.00,2.40)

1.70(1.10,2.65)

1.80(1.20,2.90)

< 0.0001

 SHR

1.06(0.87,1.34)

0.78(0.67,0.87)

1.06(1.00,1.14)

1.51(1.34,1.81)

< 0.0001

Events

     

 LOS Hospital, days

6.79(4.14,11.05)

6.79(4.17,10.81)

6.03(3.71,9.88)

7.73(4.74,12.56)

< 0.0001

 LOS ICU, days

2.20(1.25,4.15)

2.05(1.14,3.89)

2.06(1.20,3.51)

2.82(1.56,5.59)

< 0.0001

 Hospital mortality, n (%)

99(3.87)

12(1.41)

26(3.07)

61(7.10)

< 0.0001

 ICU mortality, n (%)

62(2.42)

7(0.82)

15(1.77)

40(4.66)

< 0.0001

  1. Abbreviations: SHR, stress hyperglycemia ratio; BMI, body mass index; SOFA, sequential organ failure assessment; SIRS, systemic inflammatory response syndrome; APSIII, acute physiology score III; SAPSII, simplified acute physiological score II; AMI, acute myocardial infarction; DM, diabetes mellitus; AF, atrial fibrillation/flutter; COPD, chronic obstructive pulmonary disease; AKI, acute kidney injury; CKD, chronic kidney disease; PCI, percutaneous coronary intervention; WBC, white blood cell; TC, total cholesterol; TG, triglyceride; LDL, low-density lipoprotein; HDL, high-density lipoprotein; HbA1c, hemoglobin A1c; Scr, serum creatinine; PT, prothrombin time; INR, international normalized ratio; APTT, activated partial thromboplastin time; LOS, length of stay, ICU, intensive care unit
  2. aSHR tertiles: T1 (0.103,0.933), T2 (0.933–1.223), T3 (1.223–4.311)
  3. bAKI was defined according to KDIGO guidelines as an increase in serum creatinine (Scr) by ≥ 0.3 mg/dl (≥ 26.5 µmol/l) from baseline within 48 h